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Cryopyrin-Associated Periodic Syndromes Summary

Description: A group of rare autosomal dominant diseases, commonly characterized by atypical URTICARIA (hives) with systemic symptoms that develop into end-organ damage. The atypical hives do not involve T-cell or autoantibody. Cryopyrin-associated periodic syndrome includes three previously distinct disorders: Familial cold autoinflammatory syndrome; Muckle-Wells Syndrome; and CINCA Syndrome, that are now considered to represent a disease continuum, all caused by NLRP3 protein mutations.

Also Known As: Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome; Cold Urticaria, Familial; Cold Urticarias, Familial; Cryopyrin Associated Periodic Syndromes; Cryopyrin-Associated Periodic Syndrome Show All >>

Networked: 268 relevant articles (21 outcomes, 19 trials/studies) for this Disease

Key Drugs and Agents for Cryopyrin-Associated Periodic Syndromes

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Interleukin-1 (Interleukin 1) : 7 outcomes 1 study in 63 results : IBA
  2. canakinumab : 6 outcomes 7 studies in 32 results : FDA 2
  3. Interleukin 1 Receptor Antagonist Protein (Anakinra) : 5 outcomes 3 studies in 50 results : FDA 2
  4. autosomal dominant familial Periodic fever : 3 outcomes 2 studies in 53 results : IBA
  5. rilonacept : 1 outcome 1 study in 10 results : FDA 2
  6. Interleukin-1 Receptors (Interleukin 1 Receptor) : 1 outcome in 7 results : IBA
  7. Immunoglobulin G (IgG) : 1 outcome in 2 results : IBA
  8. Thalidomide (Thalomid) : 1 outcome in 1 result : FDA 2
  9. Interleukins : 1 study in 20 results : IBA
  10. Synovitis granulomatous with uveitis and cranial neuropathies : 1 study in 17 results : IBA
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Diseases Related to Cryopyrin-Associated Periodic Syndromes

  1. Familial Mediterranean Fever (Periodic Disease)
  2. Mevalonate Kinase Deficiency
  3. Schnitzler Syndrome
  4. Arthritis (Polyarthritis)
  5. Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
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Key Therapies for Cryopyrin-Associated Periodic Syndromes

Efficacy Chart >>
  1. Aftercare (After-Treatment) : 1 outcome in 2 results
  2. Injections : 1 outcome in 1 result
  3. Kidney Transplantation : 2 results
  4. Therapeutics : 2 results
  5. Renal Dialysis (Hemodialysis) : 2 results
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