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Primary Myelofibrosis (Myelosclerosis) Summary

Description: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.

Also Known As: Myelosclerosis; Agnogenic Myeloid Metaplasia; Bone Marrow Fibrosis; Fibrosis, Bone Marrow; Myelofibrosis Show All >>

Networked: 1995 relevant articles (147 outcomes, 213 trials/studies) for this Disease

Key Drugs and Agents for Primary Myelofibrosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. INCB018424 : 30 outcomes 44 studies in 158 results : IBA
  2. Thalidomide (Thalomid) : 6 outcomes 13 studies in 51 results : FDA 2
  3. lenalidomide (CC 5013) : 6 outcomes 6 studies in 19 results : FDA 2
  4. imatinib (Gleevec) : 5 outcomes 2 studies in 34 results : FDA 3
  5. Phosphotransferases (Kinase) : 4 outcomes 10 studies in 78 results : IBA
  6. Prednisone (Sone) : 4 outcomes 7 studies in 15 results : FDA 119 Generic
  7. Interferons : 4 outcomes 5 studies in 35 results : IBA
  8. Hydroxyurea (Hydrea) : 4 outcomes 4 studies in 36 results : FDA 6 Generic
  9. Iron : 4 outcomes 4 studies in 32 results : IBA
  10. Cytarabine (Cytosar-U) : 4 outcomes in 16 results : FDA 13 Generic
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Diseases Related to Primary Myelofibrosis

  1. Primary Myelofibrosis (Myelosclerosis)
  2. Splenomegaly
  3. Anemia
  4. Thrombocytosis (Thrombocythemia)
  5. Myelodysplastic Syndromes (Myelodysplastic Syndrome)
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Key Therapies for Primary Myelofibrosis

Efficacy Chart >>
  1. Transplants (Transplant) : 7 outcomes 3 studies in 62 results
  2. Stem Cell Transplantation : 6 outcomes 6 studies in 81 results
  3. Drug Therapy (Chemotherapy) : 6 outcomes 3 studies in 61 results
  4. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 5 outcomes 2 studies in 46 results
  5. Transplantation (Transplant Recipients) : 3 outcomes 5 studies in 43 results
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