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Large Granular Lymphocytic Leukemia
Summary
Description:
A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.
Also Known As:
Leukemia, Large Granular Lymphocytic; LGL Leukemia; Large Granular Lymphocyte Leukemia; Leukemia, LGL; Leukemia, NK-LGL Show All >>
Networked: 227
relevant articles (16 outcomes,
18 trials/studies)
for this Disease
Key Drugs and Agents for Large Granular Lymphocytic Leukemia
Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
-
alemtuzumab (Campath)
:
3 outcomes 1 study in 6 results
:
FDA 2
-
Cyclosporine (Ciclosporin)
:
3 outcomes in 16 results
:
FDA 20
Generic
-
fludarabine
:
2 outcomes 1 study in 3 results
: IBA
-
Antibodies
:
2 outcomes in 10 results
: IBA
-
Antigens
:
1 outcome 2 studies in 23 results
: IBA
-
Methotrexate (Mexate)
:
1 outcome 1 study in 10 results
:
FDA 8
Generic
-
Sirolimus (Rapamycin)
:
1 outcome 1 study in 1 result
:
FDA 2
-
T-Cell Antigen Receptors (T-Cell Receptor)
:
1 outcome in 27 results
: IBA
-
Mitoxantrone (Novantrone)
:
1 outcome in 1 result
:
FDA 8
Generic
-
Dexamethasone (Maxidex)
:
1 outcome in 1 result
:
FDA 77
Generic
Show All >>
Diseases Related to Large Granular Lymphocytic Leukemia
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Neoplasms (Cancer)
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Rare Diseases (Rare Disease)
-
Pure Red-Cell Aplasia
-
Infection
-
Rheumatoid Arthritis
Show All >>
Key Therapies for Large Granular Lymphocytic Leukemia
Efficacy Chart >>
-
Splenectomy
:
1 outcome in 2 results
-
Photopheresis
:
1 outcome in 1 result
-
Therapeutics
:
1 study in 4 results
-
Kidney Transplantation
:
1 study in 3 results
-
Intravenous Infusions
:
1 study in 1 result
Show All >>
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