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Large Granular Lymphocytic Leukemia Summary

Description: A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.

Also Known As: Leukemia, Large Granular Lymphocytic; LGL Leukemia; Large Granular Lymphocyte Leukemia; Leukemia, LGL; Leukemia, NK-LGL Show All >>

Networked: 227 relevant articles (16 outcomes, 18 trials/studies) for this Disease

Key Drugs and Agents for Large Granular Lymphocytic Leukemia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. alemtuzumab (Campath) : 3 outcomes 1 study in 6 results : FDA 2
  2. Cyclosporine (Ciclosporin) : 3 outcomes in 16 results : FDA 20 Generic
  3. fludarabine : 2 outcomes 1 study in 3 results : IBA
  4. Antibodies : 2 outcomes in 10 results : IBA
  5. Antigens : 1 outcome 2 studies in 23 results : IBA
  6. Methotrexate (Mexate) : 1 outcome 1 study in 10 results : FDA 8 Generic
  7. Sirolimus (Rapamycin) : 1 outcome 1 study in 1 result : FDA 2
  8. T-Cell Antigen Receptors (T-Cell Receptor) : 1 outcome in 27 results : IBA
  9. Mitoxantrone (Novantrone) : 1 outcome in 1 result : FDA 8 Generic
  10. Dexamethasone (Maxidex) : 1 outcome in 1 result : FDA 77 Generic
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Diseases Related to Large Granular Lymphocytic Leukemia

  1. Neoplasms (Cancer)
  2. Rare Diseases (Rare Disease)
  3. Pure Red-Cell Aplasia
  4. Infection
  5. Rheumatoid Arthritis
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Key Therapies for Large Granular Lymphocytic Leukemia

Efficacy Chart >>
  1. Splenectomy : 1 outcome in 2 results
  2. Photopheresis : 1 outcome in 1 result
  3. Therapeutics : 1 study in 4 results
  4. Kidney Transplantation : 1 study in 3 results
  5. Intravenous Infusions : 1 study in 1 result
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