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Apolipoprotein E4
Summary
Description:
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Also Known As:
Apo E epsilon 4; Apo E-4; Apo E4; ApoE4; Apolipoprotein E-4 Show All >>
Networked: 1016
relevant articles (21 outcomes,
114 trials/studies)
for this Bio-Agent
Key Diseases for which Apolipoprotein E4 is
Relevant
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Alzheimer Disease (Alzheimer's Disease)
:
7 outcomes 44 studies in 525 results
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Infection
:
3 outcomes 1 study in 14 results
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Dementia (Dementias)
:
2 outcomes 13 studies in 124 results
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Atrophy
:
2 outcomes 6 studies in 34 results
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Atherosclerosis
:
2 outcomes 5 studies in 47 results
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Drugs Related to Apolipoprotein E4
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Apolipoproteins
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Apolipoprotein E4
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Apolipoproteins E (ApoE)
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Apolipoprotein E3
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Cholesterol
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Amyloid (Amyloid Fibrils)
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Lipoproteins (Lipoprotein)
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Peptides
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Carbon Monoxide
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Apolipoprotein A-I (Apolipoprotein A1)
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Therapies Related to Apolipoprotein E4
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Lithotripsy (Extracorporeal Shockwave Lithotripsy)
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Transplants (Transplant)
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Polypharmacy
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Bone Marrow Transplantation (Transplantation, Bone Marrow)
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Therapeutics
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