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Caspase 8 (Caspase-8) Summary

Description: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

Also Known As: Caspase-8; CAP4 Protease; FLICE Protein; MACH Protein; Mch5 Protease Show All >>

Networked: 1477 relevant articles (24 outcomes, 125 trials/studies) for this Bio-Agent

Key Diseases for which Caspase 8 is Relevant

  1. Neoplasms (Cancer) : 8 outcomes 27 studies in 348 results
  2. Ischemia : 3 outcomes in 23 results
  3. Neuroblastoma : 1 outcome 9 studies in 71 results
  4. Inflammation : 1 outcome 3 studies in 45 results
  5. Glioma (Gliomas) : 1 outcome 3 studies in 39 results
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Drugs Related to Caspase 8

  1. Caspase 3 (Caspase-3)
  2. Caspase 9
  3. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  4. Messenger RNA (mRNA)
  5. Proteins (Proteins, Gene)
  6. Cytochromes c (Cytochrome c)
  7. Apoptosis Regulatory Proteins
  8. Reactive Oxygen Species (Oxygen Radicals)
  9. Caspase 6
  10. Doxorubicin (Adriamycin)
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Therapies Related to Caspase 8

  1. Heterologous Transplantation (Xenotransplantation)
  2. Drug Therapy (Chemotherapy)
  3. Ligation
  4. Injections
  5. Lasers (Laser)
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