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Proteasome Endopeptidase Complex (Proteasome) Summary

Description: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.

Also Known As: Proteasome; Multicatalytic Endopeptidase Complex; 20S Proteasome; Ingensin; Macropain Show All >>

Networked: 5494 relevant articles (251 outcomes, 679 trials/studies) for this Bio-Agent

Key Diseases for which Proteasome Endopeptidase Complex is Relevant

  1. Multiple Myeloma : 84 outcomes 74 studies in 693 results
  2. Neoplasms (Cancer) : 64 outcomes 206 studies in 1608 results
  3. Hematologic Neoplasms (Hematological Malignancy) : 12 outcomes 16 studies in 104 results
  4. Neurodegenerative Diseases (Neurodegenerative Disease) : 9 outcomes 13 studies in 207 results
  5. Peripheral Nervous System Diseases (PNS Diseases) : 6 outcomes 4 studies in 30 results
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Drugs Related to Proteasome Endopeptidase Complex

  1. bortezomib (Velcade)
  2. lenalidomide (CC 5013)
  3. Ubiquitin
  4. Thalidomide (Thalomid)
  5. Proteins (Proteins, Gene)
  6. carfilzomib
  7. NF-kappa B (NF-kB)
  8. Histone Deacetylase Inhibitors
  9. benzyloxycarbonylleucyl-leucyl-leucine aldehyde
  10. Phosphotransferases (Kinase)
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Therapies Related to Proteasome Endopeptidase Complex

  1. Stem Cell Transplantation
  2. Drug Therapy (Chemotherapy)
  3. Therapeutics
  4. Heterologous Transplantation (Xenotransplantation)
  5. Molecular Targeted Therapy
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