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Sirtuins Summary

Description: A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

Also Known As: Silent Mating Type Information Regulator 2-like Proteins; Silent Mating Type Information Regulator 2 like Proteins; Sir2 like Proteins; Sir2-like Proteins

Networked: 259 relevant articles (9 outcomes, 22 trials/studies) for this Bio-Agent

Key Diseases for which Sirtuins is Relevant

  1. Neurodegenerative Diseases (Neurodegenerative Disease) : 3 outcomes 2 studies in 41 results
  2. Neoplasms (Cancer) : 2 outcomes 7 studies in 103 results
  3. Inflammation : 1 outcome 3 studies in 37 results
  4. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) : 1 outcome 2 studies in 3 results
  5. Parkinson Disease (Parkinson's Disease) : 1 outcome 1 study in 5 results
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Drugs Related to Sirtuins

  1. NAD (NADH)
  2. Enzymes
  3. PPAR gamma
  4. Histone Deacetylases (Histone Deacetylase)
  5. Chromatin
  6. NADPH Oxidase (NAD(P)H oxidase)
  8. Insulin-Like Growth Factor I (IGF-1)
  9. Apolipoproteins E (ApoE)
  10. Apolipoproteins
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Therapies Related to Sirtuins

  1. Caloric Restriction
  2. Synchrotrons

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