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Small Interfering RNA (siRNA) Summary

Description: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Also Known As: siRNA; RNA, Small Interfering; Short Hairpin RNA; Short Interfering RNA; Small Hairpin RNA; piRNA; scnRNA; shRNA; tasiRNA; Hairpin RNA, Short; Hairpin RNA, Small; Interfering RNA, Short; Interfering RNA, Small; Piwi Interacting RNA; RNA, Piwi Interacting; RNA, Short Hairpin; RNA, Short Interfering; RNA, Small Hairpin; RNA, Small Scan; Repeat Associated siRNA; Scan RNA, Small; Trans Acting siRNA; siRNA, Repeat Associated; siRNA, Trans Acting; Piwi-Interacting RNA; RNA, Piwi-Interacting; RNA, Scan; Repeat-Associated siRNA; Scan RNA; Small Scan RNA; Trans-Acting siRNA; siRNA, Repeat-Associated; siRNA, Trans-Acting

Networked: 12956 relevant articles (547 outcomes, 1542 trials/studies) for this Bio-Agent

Key Diseases for which Small Interfering RNA is Relevant

  1. Neoplasms (Cancer) : 214 outcomes 407 studies in 3897 results
  2. Infection : 41 outcomes 74 studies in 836 results
  3. Breast Neoplasms (Breast Cancer) : 29 outcomes 106 studies in 918 results
  4. Neoplasm Metastasis (Metastasis) : 22 outcomes 41 studies in 482 results
  5. Melanoma (Melanoma, Malignant) : 14 outcomes 43 studies in 421 results
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Drugs Related to Small Interfering RNA

  1. Small Interfering RNA (siRNA)
  2. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
  3. Messenger RNA (mRNA)
  4. Carbon Monoxide
  5. Paclitaxel (Taxol)
  6. NF-kappa B (NF-kB)
  7. Liposomes (Liposome)
  8. DNA (Deoxyribonucleic Acid)
  9. Polymers
  10. gemcitabine
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Therapies Related to Small Interfering RNA

  1. Heterologous Transplantation (Xenotransplantation)
  2. Drug Therapy (Chemotherapy)
  3. Therapeutics
  4. Immunotherapy
  5. Lasers (Laser)
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