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Ubiquitin Summary

Description: A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.

Also Known As: APF-1; ATP-Dependent Proteolysis Factor 1; HMG-20; High Mobility Protein 20; Ubiquitin, Human; ATP Dependent Proteolysis Factor 1; Human Ubiquitin

Networked: 5085 relevant articles (48 outcomes, 410 trials/studies) for this Bio-Agent

Key Diseases for which Ubiquitin is Relevant

  1. Neoplasms (Cancer) : 14 outcomes 48 studies in 1032 results
  2. Muscular Atrophy (Muscle Atrophy) : 5 outcomes 21 studies in 180 results
  3. Neurodegenerative Diseases (Neurodegenerative Disease) : 3 outcomes 15 studies in 338 results
  4. Frontotemporal Lobar Degeneration (Semantic Dementia) : 3 outcomes 5 studies in 290 results
  5. Fibrosis (Cirrhosis) : 3 outcomes 3 studies in 31 results
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Drugs Related to Ubiquitin

  1. Proteasome Endopeptidase Complex (Proteasome)
  2. Proteins (Proteins, Gene)
  3. Ligases
  4. protein TDP-43 (TDP-43)
  5. Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
  6. Messenger RNA (mRNA)
  7. polyglutamine
  8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  9. Calpain
  10. Dexamethasone (Maxidex)
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Therapies Related to Ubiquitin

  1. Therapeutics
  2. Drug Therapy (Chemotherapy)
  3. Homologous Transplantation (Allograft)
  4. Denervation
  5. Resuscitation
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