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Myotonic Disorders (Paramyotonia Congenita) Summary

Description: Diseases characterized by MYOTONIA, which may be inherited or acquired. Myotonia may be restricted to certain muscles (e.g., intrinsic hand muscles) or occur as a generalized condition. These disorders may be associated with abnormal muscle SODIUM CHANNEL and CHLORIDE CHANNELS. MYOTONIC DYSTROPHY and MYOTONIA CONGENITA represent two relatively common forms of this disorder. Proximal myotonic myopathy often presents with myotonia and muscle pain in early adulthood and later in life thigh muscle weakness and cataracts develop. (From Adams et al., Principles of Neurology, 6th ed, p1392)

Also Known As: Paramyotonia Congenita; Proximal Myotonic Myopathy; Eulenburg Disease; Eulenburg's Disease; PROMM (Proximal Myotonic Myopathy) Show All >>

Networked: 178 relevant articles (7 outcomes, 10 trials/studies) for this Disease

Key Drugs and Agents for Myotonic Disorders

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Mexiletine (Mexitil) : 3 outcomes 2 studies in 8 results : FDA 5 Generic
  2. Sodium Channels (Sodium Channel) : 1 outcome 2 studies in 84 results : IBA
  3. Potassium aggravated myotonia : 1 outcome 1 study in 22 results : IBA
  4. Acetazolamide (Diamox) : 1 outcome 1 study in 6 results : FDA 13 Generic
  5. Pyridostigmine Bromide (Pyridostigmine) : 1 outcome 1 study in 1 result : FDA 10 Generic
  6. Tocainide (Tonocard) : 1 outcome in 6 results : FDA 1
  7. Lidocaine (Xylocaine) : 1 outcome in 2 results : FDA 168 Generic
  8. Propafenone (Rythmol) : 1 outcome in 1 result : FDA 8 Generic
  9. Potassium : 1 study in 12 results : IBA
  10. Ion Channels (Ion Channel) : 1 study in 5 results : IBA
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Diseases Related to Myotonic Disorders

  1. Motor Neuron Disease (Primary Lateral Sclerosis)
  2. Tetany (Spasmophilia)
  3. Spasm (Spasms)
  4. Neuralgia (Stump Neuralgia)
  5. Muscle Cramp (Cramp)
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Key Therapies for Myotonic Disorders

Efficacy Chart >>
  1. Anesthesia : 4 results
  2. Gastrectomy : 1 result
  3. Electrodes (Electrode) : 1 result
  4. Drug Therapy (Chemotherapy) : 1 result
  5. Denervation : 1 result
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