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Optic Nerve Glioma Summary

Description: Glial cell derived tumors arising from the optic nerve, usually presenting in childhood. Roughly 50% are associated with NEUROFIBROMATOSIS 1. Clinical manifestations include decreased visual acuity; EXOPHTHALMOS; NYSTAGMUS, PATHOLOGIC; STRABISMUS; pallor or swelling of the optic disc; and INTRACRANIAL HYPERTENSION. The tumor may extend into the optic chiasm and hypothalamus. (Adams et al., Principles of Neurology, 6th ed, p681)

Also Known As: Adult Optic Nerve Glioma; Childhood Optic Nerve Glioma; Glioma, Optic Nerve, Adult; Glioma, Optic Nerve, Childhood; Malignant Optic Nerve Astrocytoma Show All >>

Networked: 104 relevant articles (7 outcomes, 4 trials/studies) for this Disease

Key Drugs and Agents for Optic Nerve Glioma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Retinaldehyde (Retinal) : 1 outcome in 12 results : IBA
  2. Neutralizing Antibodies : 1 outcome in 1 result : IBA
  3. Mucin-1 (CA 15-3 Antigen) : 1 outcome in 1 result : IBA
  4. Reticulin (Reticular Fiber) : 1 outcome in 1 result : IBA
  5. Glial Fibrillary Acidic Protein : 1 outcome in 1 result : IBA
  6. Sirolimus (Rapamycin) : 1 study in 2 results : FDA 2
  7. Vimentin : 1 study in 2 results : IBA
  8. Fluorodeoxyglucose F18 (Fludeoxyglucose F 18) : 1 study in 1 result : FDA 2
  9. Phosphopyruvate Hydratase (Enolase) : 1 study in 1 result : IBA
  10. Peroxidase (Myeloperoxidase) : 1 study in 1 result : IBA
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Diseases Related to Optic Nerve Glioma

  1. Neoplasms (Cancer)
  2. Glioma (Gliomas)
  3. Moyamoya Disease (Moya-Moya Disease)
  4. Metaplasia
  5. Neurofibromatosis 1 (Neurofibromatosis Type I)
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Key Therapies for Optic Nerve Glioma

Efficacy Chart >>
  1. Radiotherapy : 4 outcomes in 20 results
  2. Drug Therapy (Chemotherapy) : 1 outcome in 13 results
  3. Decompression : 1 outcome in 1 result
  4. Ventriculoperitoneal Shunt : 4 results
  5. Cranial Irradiation : 2 results
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