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3-Iodobenzylguanidine (Iobenguane) Summary

Description: A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.

Also Known As: Iobenguane; MIBG; 3-Iodobenzylguanidine, 123I Labeled; 3-Iodobenzylguanidine, 125I Labeled; Iobenguane (131I); m-Iodobenzylguanidine; meta-Iodobenzylguanidine; 123I Labeled 3-Iodobenzylguanidine; 125I Labeled 3-Iodobenzylguanidine; 3 Iodobenzylguanidine; 3 Iodobenzylguanidine, 123I Labeled; 3 Iodobenzylguanidine, 125I Labeled; m Iodobenzylguanidine; meta Iodobenzylguanidine; (3-Iodo-(131I)benzyl)guanidine

Networked: 1648 relevant articles (108 outcomes, 274 trials/studies) for this Bio-Agent

Key Diseases for which 3-Iodobenzylguanidine is Relevant

  1. Neuroblastoma : 33 outcomes 67 studies in 427 results
  2. Pheochromocytoma : 26 outcomes 24 studies in 311 results
  3. Neoplasms (Cancer) : 20 outcomes 36 studies in 376 results
  4. Heart Failure : 7 outcomes 37 studies in 137 results
  5. Paraganglioma (Paragangliomas) : 6 outcomes 6 studies in 90 results
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Drugs Related to 3-Iodobenzylguanidine

  1. 3-Iodobenzylguanidine (Iobenguane)
  2. Octreotide (Sandostatin)
  3. N-acetyltalosaminuronic acid (NAT)
  4. Iodine
  5. Guanidine (Guanidine Nitrate)
  6. Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)
  7. pentetreotide (OctreoScan)
  8. Technetium Tc 99m Medronate
  9. carvedilol (Coreg)
  10. Cholesterol
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Therapies Related to 3-Iodobenzylguanidine

  1. Drug Therapy (Chemotherapy)
  2. Radiotherapy
  3. Heterologous Transplantation (Xenotransplantation)
  4. Transplants (Transplant)
  5. Heart Transplantation (Grafting, Heart)
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