Search Login Register

Prion Diseases (Transmissible Spongiform Encephalopathies) Summary

Description: A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)

Also Known As: Transmissible Spongiform Encephalopathies; Transmissible Spongiform Encephalopathy; Prion Disease; Inherited Human Transmissible Spongiform Encephalopathies; Transmissible Dementias Show All >>

Networked: 2133 relevant articles (44 outcomes, 152 trials/studies) for this Disease

Key Drugs and Agents for Prion Diseases

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Antibodies : 4 outcomes 8 studies in 57 results : IBA
  2. Quinacrine (Mepacrine) : 4 outcomes 4 studies in 27 results : IBA
  3. Prions : 3 outcomes 27 studies in 451 results : IBA
  4. Amyloid (Amyloid Fibrils) : 3 outcomes 13 studies in 261 results : IBA
  5. Proteins (Proteins, Gene) : 2 outcomes 6 studies in 202 results : IBA
  6. Copper : 2 outcomes 1 study in 68 results : IBA
  7. RNA (Ribonucleic Acid) : 2 outcomes in 21 results : IBA
  8. PrPSc Proteins : 1 outcome 7 studies in 115 results : IBA
  9. Monoclonal Antibodies : 1 outcome 6 studies in 21 results : IBA
  10. Protein Isoforms (Isoforms) : 1 outcome 3 studies in 65 results : IBA
Show All >>

Diseases Related to Prion Diseases

  1. Alzheimer Disease (Alzheimer's Disease)
  2. Neurodegenerative Diseases (Neurodegenerative Disease)
  3. Parkinson Disease (Parkinson's Disease)
  4. Scrapie
  5. Infection
Show All >>

Key Therapies for Prion Diseases

Efficacy Chart >>
  1. Blood Transfusion (Blood Transfusions) : 1 outcome 4 studies in 34 results
  2. Therapeutics : 1 outcome 3 studies in 43 results
  3. Immunotherapy : 1 outcome 2 studies in 17 results
  4. Surgical Instruments (Clip) : 1 outcome in 10 results
  5. Transplants (Transplant) : 1 study in 13 results
Show All >>

CureHunter Inc. provides medical information and specifically does NOT provide medical advice.
© Copyright 2003-2016 CureHunter Inc., MeSH copyright NLM, Journal Articles copyright original owners.