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POEMS Syndrome (Syndrome, POEMS) Summary

Description: A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)

Also Known As: Syndrome, POEMS; Syndrome, Crow-Fukase; Polyneuropathy Organomegaly; Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome; Crow Fukase Syndrome Show All >>

Networked: 381 relevant articles (35 outcomes, 21 trials/studies) for this Disease

Key Drugs and Agents for POEMS Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. lenalidomide (CC 5013) : 6 outcomes 1 study in 17 results : FDA 2
  2. Dexamethasone (Maxidex) : 5 outcomes 1 study in 15 results : FDA 77 Generic
  3. Thalidomide (Thalomid) : 4 outcomes 3 studies in 19 results : FDA 2
  4. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor) : 3 outcomes 5 studies in 100 results : IBA
  5. Melphalan (Alkeran) : 3 outcomes 2 studies in 22 results : FDA 2 Generic
  6. bortezomib (Velcade) : 3 outcomes 1 study in 13 results : FDA 1
  7. Adrenal Cortex Hormones (Corticosteroids) : 2 outcomes in 9 results : IBA
  8. Cyclophosphamide (Cytoxan) : 2 outcomes in 7 results : FDA 10 Generic
  9. Immunoglobulins (Immunoglobulin) : 1 outcome 1 study in 16 results : IBA
  10. Multi-centric Castleman's Disease : 1 outcome 1 study in 15 results : IBA
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Diseases Related to POEMS Syndrome

  1. POEMS Syndrome (Syndrome, POEMS)
  2. Pulmonary Hypertension (Ayerza Syndrome)
  3. Polyneuropathies (Polyneuropathy)
  4. Plasmacytoma
  5. Edema
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Key Therapies for POEMS Syndrome

Efficacy Chart >>
  1. Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) : 7 outcomes in 29 results
  2. Drug Therapy (Chemotherapy) : 4 outcomes 2 studies in 23 results
  3. Stem Cell Transplantation : 2 outcomes 2 studies in 20 results
  4. Radiotherapy : 2 outcomes 1 study in 8 results
  5. Transplants (Transplant) : 2 outcomes 1 study in 7 results
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