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Synaptophysin Summary

Description: A 38-kDa integral membrane glycoprotein of the presynaptic vesicles in neuron and neuroendocrine cells. It is expressed by a variety of normal and neoplastic neuroendocrine cells and is therefore used as an immunocytochemical marker for neuroendocrine differentiation in various tumors. In ALZHEIMER DISEASE and other dementing disorders, there is an important synapse loss due in part to a decrease of synaptophysin in the presynaptic vesicles.

Also Known As: P38 Membrane Protein, Synaptic Vesicle; Protein P38, Synaptic Vesicle; Synaptophysin, Rat Clone pSR(2) Protein Moiety, Reduced

Networked: 1670 relevant articles (14 outcomes, 144 trials/studies) for this Bio-Agent

Key Diseases for which Synaptophysin is Relevant

  1. Neoplasms (Cancer) : 4 outcomes 49 studies in 866 results
  2. Stroke (Strokes) : 3 outcomes 2 studies in 14 results
  3. Alzheimer Disease (Alzheimer's Disease) : 1 outcome 10 studies in 44 results
  4. Carcinoid Tumor (Carcinoid) : 1 outcome 3 studies in 66 results
  5. Adenocarcinoma : 1 outcome 1 study in 41 results
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Drugs Related to Synaptophysin

  1. Antibodies
  2. Chromogranin A
  3. Phosphopyruvate Hydratase (Enolase)
  4. Proteins (Proteins, Gene)
  5. Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)
  6. Glial Fibrillary Acidic Protein
  7. S100 Proteins (S 100 Protein)
  8. Brain-Derived Neurotrophic Factor (BDNF)
  9. Calcium-Calmodulin-Dependent Protein Kinase Type 2
  10. Silver
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Therapies Related to Synaptophysin

  1. Lasers (Laser)
  2. Drug Therapy (Chemotherapy)
  3. Bone Marrow Transplantation (Transplantation, Bone Marrow)
  4. Electroacupuncture
  5. Surgical Instruments (Clip)
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