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Lupus Coagulation Inhibitor (Lupus Anticoagulant) Summary

Description: An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

Also Known As: Lupus Anticoagulant; Anticoagulant, Lupus; Coagulation Inhibitor, Lupus; Inhibitor, Lupus Coagulation

Networked: 1686 relevant articles (18 outcomes, 80 trials/studies) for this Bio-Agent

Key Diseases for which Lupus Coagulation Inhibitor is Relevant

  1. Thrombosis (Thrombus) : 3 outcomes 14 studies in 423 results
  2. Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) : 3 outcomes 13 studies in 316 results
  3. Lymphoma (Lymphomas) : 3 outcomes in 8 results
  4. Hypertension (High Blood Pressure) : 2 outcomes 3 studies in 26 results
  5. Systemic Lupus Erythematosus (Libman-Sacks Disease) : 1 outcome 10 studies in 234 results
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Drugs Related to Lupus Coagulation Inhibitor

  1. Anticardiolipin Antibodies
  2. Antibodies
  3. Autoantibodies
  4. Antiphospholipid Antibodies
  5. Antinuclear Antibodies
  6. Heparin (Liquaemin)
  7. Aspirin (Acetylsalicylic Acid)
  8. Anticoagulants
  9. anti-thyroglobulin
  10. Procainamide (Procan)
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Therapies Related to Lupus Coagulation Inhibitor

  1. Splenectomy
  2. Transplants (Transplant)
  3. Transplantation (Transplant Recipients)
  4. Renal Dialysis (Hemodialysis)
  5. Homologous Transplantation (Allograft)
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