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Mucopolysaccharidosis II (Hunter Syndrome) Summary

Description: Systemic lysosomal storage disease marked by progressive physical deterioration and caused by a deficiency of L-sulfoiduronate sulfatase. This disease differs from MUCOPOLYSACCHARIDOSIS I by slower progression, lack of corneal clouding, and X-linked rather than autosomal recessive inheritance. The mild form produces near-normal intelligence and life span. The severe form usually causes death by age 15.

Also Known As: Hunter Syndrome; Hunter's Syndrome; Hunter Syndrome Gargoylism; Mucopolysaccharidosis 2; Mucopolysaccharidosis Type 2 Show All >>

Networked: 236 relevant articles (12 outcomes, 19 trials/studies) for this Disease

Key Drugs and Agents for Mucopolysaccharidosis II

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. idursulfase : 6 outcomes 8 studies in 38 results : FDA 2
  2. Iduronic Acid (Iduronate) : 1 outcome in 21 results : IBA
  3. Enzymes : 1 outcome in 10 results : IBA
  4. iduronate 2-sulfate : 1 outcome in 4 results : IBA
  5. Plastics : 1 outcome in 1 result : IBA
  6. Complementary DNA (cDNA) : 2 studies in 13 results : IBA
  7. Glycosaminoglycans : 1 study in 46 results : IBA
  8. Iduronate Sulfatase : 1 study in 20 results : IBA
  9. DNA (Deoxyribonucleic Acid) : 1 study in 14 results : IBA
  10. Messenger RNA (mRNA) : 1 study in 3 results : IBA
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Diseases Related to Mucopolysaccharidosis II

  1. Mucopolysaccharidoses
  2. Mucopolysaccharidosis I (Hurler Syndrome)
  3. Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
  4. Fabry Disease (Fabry's Disease)
  5. Gaucher Disease (Gaucher's Disease)
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Key Therapies for Mucopolysaccharidosis II

Efficacy Chart >>
  1. Enzyme Replacement Therapy : 3 outcomes 7 studies in 48 results
  2. Stents : 1 outcome in 2 results
  3. Continuous Positive Airway Pressure : 1 outcome in 1 result
  4. Hematopoietic Stem Cell Transplantation : 1 study in 4 results
  5. Plasma Exchange : 1 study in 1 result
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