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Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) Summary

Description: Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).

Also Known As: Bare Lymphocyte Syndrome; Immunodeficiency Syndrome, Severe Combined; Immunologic Deficiency, Severe Combined; Omenn's Syndrome; Reticuloendotheliosis, Familial Show All >>

Networked: 2083 relevant articles (58 outcomes, 157 trials/studies) for this Disease

Key Drugs and Agents for Severe Combined Immunodeficiency

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Adenosine Deaminase : 6 outcomes 21 studies in 223 results : IBA
  2. Antibodies : 4 outcomes 3 studies in 29 results : IBA
  3. matrigel : 2 outcomes 1 study in 8 results : IBA
  4. Immunotoxins (Immunotoxin) : 2 outcomes in 8 results : IBA
  5. LBH589 : 2 outcomes in 2 results : IBA
  6. Severe combined immunodeficiency due to adenosine deaminase deficiency : 1 outcome 3 studies in 73 results : IBA
  7. Immunoglobulin G (IgG) : 1 outcome 3 studies in 36 results : IBA
  8. Complementary DNA (cDNA) : 1 outcome 2 studies in 11 results : IBA
  9. Immunoglobulins (Immunoglobulin) : 1 outcome 1 study in 28 results : IBA
  10. Streptozocin (Streptozotocin) : 1 outcome 1 study in 17 results : FDA 1
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Diseases Related to Severe Combined Immunodeficiency

  1. Infection
  2. Neoplasms (Cancer)
  3. Leukemia
  4. Melanoma (Melanoma, Malignant)
  5. Wiskott-Aldrich Syndrome (Syndrome, Wiskott-Aldrich)
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Key Therapies for Severe Combined Immunodeficiency

Efficacy Chart >>
  1. Hematopoietic Stem Cell Transplantation : 4 outcomes in 45 results
  2. Transplantation (Transplant Recipients) : 3 outcomes 8 studies in 184 results
  3. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 3 outcomes 2 studies in 151 results
  4. Drug Therapy (Chemotherapy) : 2 outcomes 2 studies in 19 results
  5. Injections : 2 outcomes 1 study in 12 results
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