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1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium) Summary

Description: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

Also Known As: 1 Methyl 4 phenylpyridinium; 1-Methyl-4-phenylpyridine; 1-Methyl-4-phenylpyridinium Chloride; 1-Methyl-4-phenylpyridinium Ion; N-Methyl-4-phenylpyridine Show All >>

Networked: 254 relevant articles (13 outcomes, 50 trials/studies) for this Bio-Agent

Key Diseases for which 1-Methyl-4-phenylpyridinium is Relevant

  1. Neuroblastoma : 7 outcomes 14 studies in 44 results
  2. Parkinson Disease (Parkinson's Disease) : 6 outcomes 21 studies in 111 results
  3. Pheochromocytoma : 3 outcomes 4 studies in 22 results
  4. Parkinsonian Disorders (Parkinsonism) : 1 outcome 8 studies in 66 results
  5. Necrosis : 1 study in 2 results
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Drugs Related to 1-Methyl-4-phenylpyridinium

  1. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
  2. Dopamine (Intropin)
  3. Oxidopamine (6 Hydroxydopamine)
  4. Hydrogen Peroxide (Hydroperoxide)
  5. Neurotoxins
  6. Monoamine Oxidase (MAO)
  7. Amyloid (Amyloid Fibrils)
  8. Smoke
  9. Protein Kinases (Protein Kinase)
  10. acetamide
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Therapies Related to 1-Methyl-4-phenylpyridinium

  1. Oral Administration

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