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BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) Summary

Description: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.

Also Known As: Chronic Myelogenous Leukemia; Chronic Myeloid Leukemia; Leukemia, Myeloid, Philadelphia Positive; Chronic Granulocytic Leukemia; Leukemia, Chronic Myelogenous Show All >>

Networked: 9684 relevant articles (879 outcomes, 955 trials/studies) for this Disease

Key Drugs and Agents for BCR-ABL Positive Chronic Myelogenous Leukemia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. imatinib (Gleevec) : 405 outcomes 309 studies in 2864 results : FDA 3
  2. Protein-Tyrosine Kinases (Tyrosine Kinase) : 139 outcomes 69 studies in 1391 results : IBA
  3. Interferon-alpha (Interferon Alfa) : 74 outcomes 69 studies in 559 results : FDA 2
  4. dasatinib (BMS 354825) : 54 outcomes 50 studies in 410 results : FDA 2
  5. Interferons : 36 outcomes 53 studies in 317 results : IBA
  6. 4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib) : 36 outcomes 43 studies in 313 results : FDA 1
  7. Bcr-Abl tyrosine kinase : 31 outcomes 8 studies in 259 results : IBA
  8. Phosphotransferases (Kinase) : 30 outcomes 21 studies in 555 results : IBA
  9. Busulfan (Busulfex) : 20 outcomes 19 studies in 233 results : FDA 2
  10. Cytarabine (Cytosar-U) : 13 outcomes 38 studies in 161 results : FDA 13 Generic
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Diseases Related to BCR-ABL Positive Chronic Myelogenous Leukemia

  1. Leukemia
  2. Philadelphia Chromosome
  3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
  4. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
  5. Blast Crisis (Blast Phase)
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Key Therapies for BCR-ABL Positive Chronic Myelogenous Leukemia

Efficacy Chart >>
  1. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 60 outcomes 35 studies in 610 results
  2. Transplants (Transplant) : 45 outcomes 21 studies in 409 results
  3. Stem Cell Transplantation : 28 outcomes 17 studies in 238 results
  4. Transplantation (Transplant Recipients) : 26 outcomes 22 studies in 287 results
  5. Drug Therapy (Chemotherapy) : 24 outcomes 14 studies in 299 results
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