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Chagas Disease (American Trypanosomiasis) Summary

Description: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.

Also Known As: American Trypanosomiasis; South American Trypanosomiasis; Chagas' Disease; Disease, Chagas; Disease, Chagas' Show All >>

Networked: 2751 relevant articles (116 outcomes, 273 trials/studies) for this Disease

Key Drugs and Agents for Chagas Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. benzonidazole (benznidazole) : 24 outcomes 26 studies in 225 results : IBA
  2. Nifurtimox : 13 outcomes 8 studies in 109 results : IBA
  3. Antigens : 11 outcomes 22 studies in 289 results : IBA
  4. Allopurinol (Remid) : 7 outcomes 3 studies in 24 results : FDA 25 Generic
  5. Antibodies : 6 outcomes 14 studies in 214 results : IBA
  6. posaconazole : 4 outcomes 6 studies in 24 results : FDA 2
  7. Ketoconazole (Nizoral) : 4 outcomes 2 studies in 14 results : FDA 20 Generic
  8. Complement System Proteins (Complement) : 3 outcomes 6 studies in 84 results : IBA
  9. Itraconazole (Sporanox) : 3 outcomes 3 studies in 15 results : FDA 6 Generic
  10. Gentian Violet (Violet, Crystal) : 3 outcomes 1 study in 19 results : FDA 2
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Diseases Related to Chagas Disease

  1. Infection
  2. Leishmaniasis
  3. Myocarditis (Carditis)
  4. Chagas Disease (American Trypanosomiasis)
  5. African Trypanosomiasis (Nagana)
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Key Therapies for Chagas Disease

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 5 outcomes 21 studies in 173 results
  2. Transplantation (Transplant Recipients) : 4 outcomes 1 study in 36 results
  3. Heart Transplantation (Grafting, Heart) : 2 outcomes 6 studies in 44 results
  4. Blood Transfusion (Blood Transfusions) : 2 outcomes 5 studies in 92 results
  5. Transplants (Transplant) : 1 outcome 2 studies in 50 results
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