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Androgen-Insensitivity Syndrome (Testicular Feminization) Summary

Description: A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.

Also Known As: Testicular Feminization; Reifenstein Syndrome; Reifenstein's Syndrome; Androgen Receptor Deficiency; Androgen-Insensitivity Syndrome, Complete Show All >>

Networked: 725 relevant articles (5 outcomes, 62 trials/studies) for this Disease

Key Drugs and Agents for Androgen-Insensitivity Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Testosterone (Sustanon) : 2 outcomes 7 studies in 72 results : FDA 13
  2. Dihydrotestosterone (Androstanolone) : 2 outcomes 5 studies in 33 results : IBA
  3. Hormones : 1 outcome 4 studies in 43 results : IBA
  4. Steroids : 1 outcome in 15 results : IBA
  5. Cholestenone 5 alpha-Reductase (5 alpha-Reductase) : 1 outcome in 13 results : IBA
  6. Nitrogen : 1 outcome in 3 results : IBA
  7. Androstenedione (4 Androstene 3,17 dione) : 1 outcome in 2 results : IBA
  8. Esters : 1 outcome in 1 result : IBA
  9. Androgen Receptors (Androgen Receptor) : 24 studies in 366 results : IBA
  10. Androgens : 7 studies in 55 results : IBA
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Diseases Related to Androgen-Insensitivity Syndrome

  1. Gonadal Dysgenesis (Gonadal Agenesis)
  2. Virilism (Virilization)
  3. Hyperthyroidism
  4. Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
  5. XY Disorders of Sex Development 46 (Male Pseudohermaphroditism)
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Key Therapies for Androgen-Insensitivity Syndrome

Efficacy Chart >>
  1. Laparotomy : 1 outcome in 3 results
  2. Castration : 1 study in 6 results
  3. Contraception (Birth Control) : 1 study in 1 result
  4. Orchiectomy (Orchidectomy) : 13 results
  5. Individualized Medicine : 2 results
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