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Sulindac (Copal) Summary

Description: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.

Also Known As: Copal; Clinoril; Aclin; Alphapharm Brand of Sulindac; Apo-Sulin Show All >>

Networked: 815 relevant articles (90 outcomes, 184 trials/studies) for this Drug

Key Diseases for which Sulindac is Relevant

  1. Neoplasms (Cancer) : 18 outcomes 33 studies in 198 results
  2. Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) : 11 outcomes 20 studies in 102 results
  3. Polyps : 11 outcomes 16 studies in 85 results
  4. Adenoma (Adenomas) : 10 outcomes 16 studies in 85 results
  5. Colonic Neoplasms (Colon Cancer) : 6 outcomes 12 studies in 67 results
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Drugs Related to Sulindac

  1. Ibuprofen (Motrin)
  2. Tamoxifen
  3. Indomethacin (Indometacin)
  4. Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
  5. Aspirin (Acetylsalicylic Acid)
  6. celecoxib (Celebrex)
  7. Naproxen (Naprosyn)
  8. Piroxicam (Feldene)
  9. Diclofenac (SR 38)
  10. Tolmetin (Tolmetin Sodium)
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Therapies Related to Sulindac

  1. Colectomy
  2. Chemoprevention
  3. Heterologous Transplantation (Xenotransplantation)
  4. Drug Therapy (Chemotherapy)
  5. Radiotherapy
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