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Subacute Sclerosing Panencephalitis (SSPE) Summary

Description: A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)

Also Known As: SSPE; Subacute Sclerosing Leukoencephalitis; Encephaltis, Inclusion Body, Measles; Inclusion Body Encephalitis, Measles; Leukoencephalitis, Van Bogaert's Show All >>

Networked: 718 relevant articles (28 outcomes, 63 trials/studies) for this Disease

Key Drugs and Agents for Subacute Sclerosing Panencephalitis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Inosine Pranobex (Imunovir) : 9 outcomes 11 studies in 59 results : IBA
  2. Interferons : 6 outcomes 4 studies in 50 results : IBA
  3. Interferon-alpha (Interferon Alfa) : 3 outcomes 5 studies in 49 results : FDA 2
  4. Ribavirin (Virazole) : 3 outcomes 4 studies in 22 results : FDA 16 Generic
  5. Antigens : 1 outcome 7 studies in 72 results : IBA
  6. Antibodies : 1 outcome 5 studies in 109 results : IBA
  7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor) : 1 outcome 2 studies in 10 results : IBA
  8. Interferon-beta : 1 outcome 2 studies in 7 results : IBA
  9. Carbon Monoxide : 1 outcome 1 study in 13 results : IBA
  10. Glucose (Dextrose) : 1 outcome 1 study in 6 results : FDA 175 Generic
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Diseases Related to Subacute Sclerosing Panencephalitis

  1. Subacute Sclerosing Panencephalitis (SSPE)
  2. Measles
  3. Infection
  4. Myoclonus (Nocturnal Myoclonus)
  5. Neoplasms (Cancer)
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Key Therapies for Subacute Sclerosing Panencephalitis

Efficacy Chart >>
  1. Radiotherapy : 1 outcome 1 study in 1 result
  2. Amputation : 1 outcome in 1 result
  3. Aftercare (After-Treatment) : 1 outcome in 1 result
  4. Immunomodulation : 1 study in 1 result
  5. Drug Therapy (Chemotherapy) : 3 results
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