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Subacute Sclerosing Panencephalitis
(SSPE)
Summary
Description:
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
Also Known As:
SSPE; Subacute Sclerosing Leukoencephalitis; Encephaltis, Inclusion Body, Measles; Inclusion Body Encephalitis, Measles; Leukoencephalitis, Van Bogaert's Show All >>
Networked: 718
relevant articles (28 outcomes,
63 trials/studies)
for this Disease
Key Drugs and Agents for Subacute Sclerosing Panencephalitis
Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
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Inosine Pranobex (Imunovir)
:
9 outcomes 11 studies in 59 results
: IBA
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Interferons
:
6 outcomes 4 studies in 50 results
: IBA
-
Interferon-alpha (Interferon Alfa)
:
3 outcomes 5 studies in 49 results
:
FDA 2
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Ribavirin (Virazole)
:
3 outcomes 4 studies in 22 results
:
FDA 16
Generic
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Antigens
:
1 outcome 7 studies in 72 results
: IBA
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Antibodies
:
1 outcome 5 studies in 109 results
: IBA
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Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
:
1 outcome 2 studies in 10 results
: IBA
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Interferon-beta
:
1 outcome 2 studies in 7 results
: IBA
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Carbon Monoxide
:
1 outcome 1 study in 13 results
: IBA
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Glucose (Dextrose)
:
1 outcome 1 study in 6 results
:
FDA 175
Generic
Show All >>
Diseases Related to Subacute Sclerosing Panencephalitis
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Subacute Sclerosing Panencephalitis (SSPE)
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Measles
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Infection
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Myoclonus (Nocturnal Myoclonus)
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Neoplasms (Cancer)
Show All >>
Key Therapies for Subacute Sclerosing Panencephalitis
Efficacy Chart >>
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Radiotherapy
:
1 outcome 1 study in 1 result
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Amputation
:
1 outcome in 1 result
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Aftercare (After-Treatment)
:
1 outcome in 1 result
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Immunomodulation
:
1 study in 1 result
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Drug Therapy (Chemotherapy)
:
3 results
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