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Spironolactone (Aldactone) Summary

Description: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)

Also Known As: Aldactone; Aldactone A; Alphapharm Brand of Spironolactone; Alpharma Brand of Spironolactone; Alter Brand of Spironolactone Show All >>

Networked: 2197 relevant articles (262 outcomes, 439 trials/studies) for this Drug

Key Diseases for which Spironolactone is Relevant

  1. Heart Failure : 70 outcomes 157 studies in 489 results
  2. Hypertension (High Blood Pressure) : 40 outcomes 70 studies in 403 results
  3. Hirsutism : 31 outcomes 15 studies in 114 results
  4. Respiratory Sounds (Crackle) : 17 outcomes 85 studies in 88 results
  5. Fibrosis (Cirrhosis) : 17 outcomes 24 studies in 174 results
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Drugs Related to Spironolactone

  1. Aldosterone
  2. eplerenone (Inspra)
  3. Spironolactone (Aldactone)
  4. Furosemide (Lasix)
  5. Potassium
  6. Renin
  7. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
  8. Mineralocorticoid Receptors (Mineralocorticoid Receptor)
  9. Cyproterone Acetate
  10. Flutamide (Eulexin)
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Therapies Related to Spironolactone

  1. Adrenalectomy
  2. Renal Dialysis (Hemodialysis)
  3. Denervation
  4. Sodium-Restricted Diet (Diet, Sodium Restricted)
  5. Continuous Ambulatory Peritoneal Dialysis (CAPD)
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