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Infantile Spasms (West Syndrome) Summary

Description: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)

Also Known As: West Syndrome; Lightning Attack; Infantile Spasm; Spasmus Nutans; Spasms, Infantile Show All >>

Networked: 1132 relevant articles (162 outcomes, 147 trials/studies) for this Disease

Key Drugs and Agents for Infantile Spasms

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Adrenocorticotropic Hormone (ACTH) : 62 outcomes 44 studies in 339 results : FDA 7
  2. Vigabatrin : 52 outcomes 38 studies in 198 results : FDA 2
  3. Lennox-Gastaut type Epileptic encephalopathy : 21 outcomes 20 studies in 209 results : IBA
  4. topiramate (Topamax) : 14 outcomes 10 studies in 36 results : FDA 28 Generic
  5. Valproic Acid (Valproate, Semisodium) : 11 outcomes 3 studies in 48 results : FDA 51 Generic
  6. zonisamide (Zonegran) : 10 outcomes 5 studies in 26 results : FDA 19 Generic
  7. lamotrigine (Lamictal) : 9 outcomes in 19 results : FDA 33 Generic
  8. Anticonvulsants (Antiepileptic Drugs) : 6 outcomes 1 study in 55 results : IBA
  9. felbamate (Felbatol) : 6 outcomes 1 study in 10 results : FDA 1
  10. Vitamin B 6 : 5 outcomes 2 studies in 18 results : IBA
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Diseases Related to Infantile Spasms

  1. Seizures (Seizure)
  2. Infantile Spasms (West Syndrome)
  3. Tuberous Sclerosis (Bourneville's Disease)
  4. Epilepsy (Aura)
  5. Spasm (Spasms)
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Key Therapies for Infantile Spasms

Efficacy Chart >>
  1. Ketogenic Diet : 7 outcomes 5 studies in 24 results
  2. Carbohydrate-Restricted Diet (Low Carbohydrate Diet) : 1 outcome 2 studies in 2 results
  3. Hemispherectomy : 1 outcome in 4 results
  4. Drug Therapy (Chemotherapy) : 2 studies in 7 results
  5. Prenatal Care : 1 study in 2 results
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