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Kaposi Sarcoma (Kaposi's Sarcoma) Summary

Description: A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.

Also Known As: Kaposi's Sarcoma; Sarcoma, Kaposi; Kaposis Sarcoma; Sarcoma, Kaposi's

Networked: 3383 relevant articles (199 outcomes, 286 trials/studies) for this Disease

Key Drugs and Agents for Kaposi Sarcoma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Doxorubicin (Adriamycin) : 19 outcomes 15 studies in 86 results : FDA 12 Generic
  2. Interferon-alpha (Interferon Alfa) : 19 outcomes 10 studies in 114 results : FDA 2
  3. Paclitaxel (Taxol) : 12 outcomes 7 studies in 60 results : FDA 13 Generic
  4. pegylated liposomal doxorubicin : 11 outcomes 9 studies in 35 results : IBA
  5. Interferons : 8 outcomes 11 studies in 98 results : IBA
  6. Zidovudine (Retrovir) : 7 outcomes 12 studies in 47 results : FDA 42 Generic
  7. Vinblastine (Vinblastine Sulfate) : 7 outcomes 9 studies in 45 results : FDA 7
  8. Sirolimus (Rapamycin) : 7 outcomes 4 studies in 57 results : FDA 2
  9. Vincristine (Oncovin) : 6 outcomes 8 studies in 44 results : FDA 17 Generic
  10. Etoposide (VP 16) : 5 outcomes 8 studies in 22 results : FDA 16 Generic
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Diseases Related to Kaposi Sarcoma

  1. Acquired Immunodeficiency Syndrome (AIDS)
  2. Neoplasms (Cancer)
  3. Non-Hodgkin Lymphoma (Lymphosarcoma)
  4. Lymphoma (Lymphomas)
  5. Melanoma (Melanoma, Malignant)
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Key Therapies for Kaposi Sarcoma

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 25 outcomes 20 studies in 173 results
  2. Highly Active Antiretroviral Therapy (HAART) : 20 outcomes 16 studies in 191 results
  3. Radiotherapy : 11 outcomes 3 studies in 91 results
  4. Transplants (Transplant) : 4 outcomes 8 studies in 233 results
  5. Aftercare (After-Treatment) : 3 outcomes in 9 results
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