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Restless Legs Syndrome (Restless Legs) Summary

Description: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence. This condition may be associated with UREMIA; DIABETES MELLITUS; and rheumatoid arthritis. Restless Legs Syndrome differs from NOCTURNAL MYOCLONUS SYNDROME in that in the latter condition the individual does not report adverse sensory stimuli and it is primarily a sleep-associated movement disorder. (Adams et al., Principles of Neurology, 6th ed, p387; Schweiz Rundsch Med Prax 1997 Apr 30;86(18):732-736)

Also Known As: Restless Legs; Ekbom's Syndrome; Ekboms Syndrome; Syndrome, Ekbom; Syndrome, Ekbom's Show All >>

Networked: 1004 relevant articles (109 outcomes, 203 trials/studies) for this Disease

Key Drugs and Agents for Restless Legs Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Dopamine Agonists (Dopamine Agonist) : 18 outcomes 21 studies in 132 results : IBA
  2. pramipexol (pramipexole) : 13 outcomes 20 studies in 84 results : FDA 1 Generic
  3. Iron : 10 outcomes 27 studies in 145 results : IBA
  4. Levodopa (L Dopa) : 10 outcomes 17 studies in 67 results : FDA 31 Generic
  5. ropinirole (Requip) : 9 outcomes 24 studies in 66 results : FDA 11 Generic
  6. N 0437 : 8 outcomes 17 studies in 52 results : FDA 1
  7. Dopamine Agents (Dopaminergic Agents) : 7 outcomes 4 studies in 51 results : IBA
  8. 1- (((alpha- isobutanoyloxyethoxy)carbonyl)aminomethyl)- 1- cyclohexaneacetic acid : 6 outcomes 12 studies in 32 results : IBA
  9. Opioid Analgesics (Opioids) : 6 outcomes 4 studies in 22 results : IBA
  10. Pergolide (Permax) : 5 outcomes 6 studies in 20 results : FDA 3
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Diseases Related to Restless Legs Syndrome

  1. Parkinson Disease (Parkinson's Disease)
  2. Pain (Aches)
  3. Restless Legs Syndrome (Restless Legs)
  4. Sleep Initiation and Maintenance Disorders (Insomnia)
  5. Schizophrenia (Dementia Praecox)
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Key Therapies for Restless Legs Syndrome

Efficacy Chart >>
  1. Transdermal Patch : 4 outcomes 6 studies in 16 results
  2. Renal Dialysis (Hemodialysis) : 2 outcomes 7 studies in 48 results
  3. Deep Brain Stimulation : 1 outcome 1 study in 6 results
  4. Aftercare (After-Treatment) : 1 outcome 1 study in 6 results
  5. Kidney Transplantation : 2 studies in 8 results
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