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Epidermal Growth Factor Receptor (EGF Receptor) Summary

Description: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.

Also Known As: EGF Receptor; Receptor, Epidermal Growth Factor; Epidermal Growth Factor Receptor Kinase; Receptors, Epidermal Growth Factor; Epidermal Growth Factor Receptor Protein Tyrosine Kinase Show All >>

Networked: 16151 relevant articles (732 outcomes, 1830 trials/studies) for this Bio-Agent

Key Diseases for which Epidermal Growth Factor Receptor is Relevant

  1. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) : 208 outcomes 255 studies in 2090 results
  2. Neoplasms (Cancer) : 165 outcomes 468 studies in 5635 results
  3. Breast Neoplasms (Breast Cancer) : 113 outcomes 318 studies in 2314 results
  4. Colorectal Neoplasms (Colorectal Cancer) : 68 outcomes 98 studies in 876 results
  5. Lung Neoplasms (Lung Cancer) : 68 outcomes 94 studies in 983 results
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Drugs Related to Epidermal Growth Factor Receptor

  1. Protein-Tyrosine Kinases (Tyrosine Kinase)
  2. gefitinib (Iressa)
  3. trastuzumab (Herceptin)
  4. erlotinib (CP 358,774)
  5. cetuximab (Erbitux)
  6. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
  7. Monoclonal Antibodies
  8. Epidermal Growth Factor (EGF)
  9. lapatinib (GW572016)
  10. gemcitabine
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Therapies Related to Epidermal Growth Factor Receptor

  1. Drug Therapy (Chemotherapy)
  2. Radiotherapy
  3. Heterologous Transplantation (Xenotransplantation)
  4. Therapeutics
  5. Immunotherapy
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