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Pyruvate Carboxylase Summary

Description: A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.

Also Known As: Carboxylase, Pyruvate; Pyruvate:carbon-dioxide ligase (ADP-forming)

Networked: 97 relevant articles (0 outcomes, 9 trials/studies) for this Bio-Agent

Key Diseases for which Pyruvate Carboxylase is Relevant

  1. Neoplasms (Cancer) : 2 studies in 8 results
  2. Leigh Disease (Leigh's Disease) : 2 studies in 5 results
  3. Pyruvate Carboxylase Deficiency Disease : 1 study in 5 results
  4. Diffuse Cerebral Sclerosis of Schilder (Alpers' Disease) : 1 study in 2 results
  5. Seizures (Seizure) : 1 study in 1 result
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Drugs Related to Pyruvate Carboxylase

  1. Glucose (Dextrose)
  2. Glutamine (L-Glutamine)
  3. Glutamic Acid (Glutamate)
  4. Pyruvate Decarboxylase (Decarboxylase, Pyruvate)
  5. Dihydrolipoamide Dehydrogenase (Lipoamide Dehydrogenase)
  6. Halothane (Fluothane)
  7. Bicuculline
  8. Alanine (L-Alanine)
  9. triheptanoin
  10. Biotin (Vitamin H)
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Therapies Related to Pyruvate Carboxylase

  1. Intravenous Infusions
  2. Ovariectomy (Oophorectomy)
  3. Drug Therapy (Chemotherapy)

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