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Progeria
(Hutchinson Gilford Syndrome)
Summary
Description:
An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
Also Known As:
Hutchinson Gilford Syndrome; Syndrome, Hutchinson-Gilford; Hutchinson-Gilford Syndrome
Networked: 261
relevant articles (6 outcomes,
16 trials/studies)
for this Disease
Key Drugs and Agents for Progeria
Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
-
prelamin A
:
2 outcomes 2 studies in 30 results
: IBA
-
Lamin Type A (Lamin A)
:
1 outcome 3 studies in 60 results
: IBA
-
Enzymes
:
1 outcome 2 studies in 8 results
: IBA
-
Farnesyltranstransferase (Farnesyltransferase)
:
1 outcome in 6 results
: IBA
-
Adenosine Triphosphate (ATP)
:
1 outcome in 3 results
: IBA
-
p21(ras) farnesyl-protein transferase (protein farnesyltransferase)
:
1 outcome in 2 results
: IBA
-
Staphylococcal Protein A (A, Protein)
:
1 outcome in 1 result
: IBA
-
Lovastatin (Mevacor)
:
1 outcome in 1 result
:
FDA 14
Generic
-
Reactive Oxygen Species (Oxygen Radicals)
:
2 studies in 2 results
: IBA
-
Hutchinson Gilford progeria syndrome
:
1 study in 23 results
: IBA
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Diseases Related to Progeria
-
Werner Syndrome (Werner's Syndrome)
-
Premature Aging
-
Down Syndrome (Down's Syndrome)
-
Neoplasms (Cancer)
-
Cockayne Syndrome (Syndrome, Cockayne)
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Key Therapies for Progeria
Efficacy Chart >>
-
Transplants (Transplant)
:
1 result
-
Prostheses and Implants (Prosthesis)
:
1 result
-
Transplantation (Transplant Recipients)
:
1 result
-
Therapeutics
:
1 result
-
Oral Surgery (Maxillofacial Surgery)
:
1 result
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