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Prions Summary

Description: Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.

Also Known As: Encephalopathy Virus, Mink; Mink Encephalopathy Virus; PrP Proteins; Prion Proteins

Networked: 1349 relevant articles (16 outcomes, 83 trials/studies) for this Bio-Agent

Key Diseases for which Prions is Relevant

  1. Infection : 4 outcomes 13 studies in 216 results
  2. Prion Diseases (Transmissible Spongiform Encephalopathies) : 3 outcomes 27 studies in 451 results
  3. Scrapie : 3 outcomes 25 studies in 385 results
  4. Neurodegenerative Diseases (Neurodegenerative Disease) : 1 outcome 5 studies in 224 results
  5. Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) : 1 outcome 4 studies in 200 results
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Drugs Related to Prions

  1. Amyloid (Amyloid Fibrils)
  2. Protein Isoforms (Isoforms)
  3. Synucleins
  4. Doxycycline (Vibramycin)
  5. Ligands
  6. Suramin (Suramin Sodium)
  7. Ethanol (Ethyl Alcohol)
  8. Pattern Recognition Receptors
  9. Molecular Chaperones (Chaperone, Molecular)
  10. phenothiazine
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Therapies Related to Prions

  1. Homologous Transplantation (Allograft)
  2. Transplants (Transplant)
  3. Immunotherapy
  4. Quantum Dots (Quantum Dot)
  5. Laryngoscopes
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