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Tissue Plasminogen Activator (Alteplase) Summary

Description: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

Also Known As: Alteplase; Activase; T-Plasminogen Activator; Actilyse; Boehringer Ingelheim Brand of Alteplase Show All >>

Networked: 6817 relevant articles (584 outcomes, 1223 trials/studies) for this Drug

Key Diseases for which Tissue Plasminogen Activator is Relevant

  1. Stroke (Strokes) : 299 outcomes 564 studies in 2704 results
  2. Myocardial Infarction : 56 outcomes 273 studies in 860 results
  3. Thrombosis (Thrombus) : 42 outcomes 49 studies in 630 results
  4. Hemorrhage : 37 outcomes 61 studies in 486 results
  5. Pulmonary Embolism : 12 outcomes 26 studies in 181 results
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Drugs Related to Tissue Plasminogen Activator

  1. Tissue Plasminogen Activator (Alteplase)
  2. Urokinase-Type Plasminogen Activator (Urokinase)
  3. Streptokinase
  4. Heparin (Liquaemin)
  5. Plasminogen Activators (Plasminogen Activator)
  6. tenecteplase
  7. Fibrin
  8. Aspirin (Acetylsalicylic Acid)
  9. Plasminogen Activator Inhibitor 1
  10. 4- Acetamido- 4'- isothiocyanatostilbene- 2,2'- disulfonic Acid (SITS)
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Therapies Related to Tissue Plasminogen Activator

  1. Thrombolytic Therapy
  2. Catheters
  3. Injections
  4. Vitrectomy
  5. Angioplasty (Angioplasty, Transluminal)
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