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Multiple Sclerosis Summary

Description: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Also Known As: Disseminated Sclerosis; Sclerosis, Multiple; MS (Multiple Sclerosis); Multiple Sclerosis, Acute Fulminating; Sclerosis, Disseminated

Networked: 18452 relevant articles (932 outcomes, 2499 trials/studies) for this Disease

Key Drugs and Agents for Multiple Sclerosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. natalizumab (Tysabri) : 59 outcomes 92 studies in 616 results : FDA 2
  2. Interferon-beta : 58 outcomes 99 studies in 915 results : IBA
  3. fingolimod (FTY720) : 52 outcomes 84 studies in 438 results : FDA 1
  4. copolymer 1 (glatiramer acetate) : 45 outcomes 80 studies in 474 results : FDA 1
  5. Interferons : 42 outcomes 95 studies in 641 results : IBA
  6. Methylprednisolone : 21 outcomes 40 studies in 230 results : FDA 18 Generic
  7. interferon beta 1a : 19 outcomes 99 studies in 286 results : FDA 3
  8. Antibodies : 19 outcomes 69 studies in 853 results : IBA
  9. Mitoxantrone (Novantrone) : 18 outcomes 40 studies in 209 results : FDA 8 Generic
  10. Cannabinoids : 17 outcomes 28 studies in 109 results : IBA
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Diseases Related to Multiple Sclerosis

  1. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
  2. Autoimmune Diseases (Autoimmune Disease)
  3. Rheumatoid Arthritis
  4. Demyelinating Diseases (Demyelinating Disease)
  5. Pain (Aches)
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Key Therapies for Multiple Sclerosis

Efficacy Chart >>
  1. Injections : 9 outcomes 17 studies in 101 results
  2. Immunotherapy : 9 outcomes 15 studies in 175 results
  3. Transplantation (Transplant Recipients) : 8 outcomes 19 studies in 91 results
  4. Immunomodulation : 8 outcomes 16 studies in 124 results
  5. Drug Therapy (Chemotherapy) : 8 outcomes 10 studies in 91 results
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