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Mixed Connective Tissue Disease (MCTD) Summary

Description: A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.

Also Known As: MCTD; Syndrome, Sharp; Connective Tissue Disease, Mixed; Sharp Syndrome

Networked: 786 relevant articles (22 outcomes, 41 trials/studies) for this Disease

Key Drugs and Agents for Mixed Connective Tissue Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Adrenal Cortex Hormones (Corticosteroids) : 3 outcomes 1 study in 17 results : IBA
  2. Antibodies : 2 outcomes 6 studies in 233 results : IBA
  3. Antineutrophil Cytoplasmic Antibodies (ANCA) : 2 outcomes 1 study in 15 results : IBA
  4. Prednisolone (Predate) : 2 outcomes in 17 results : FDA 55 Generic
  5. Cyclophosphamide (Cytoxan) : 2 outcomes in 14 results : FDA 10 Generic
  6. Cyclosporine (Ciclosporin) : 2 outcomes in 5 results : FDA 20 Generic
  7. Autoantibodies : 1 outcome 9 studies in 94 results : IBA
  8. bosentan (Tracleer) : 1 outcome 2 studies in 5 results : FDA 1
  9. Small Nuclear Ribonucleoproteins (snRNP) : 1 outcome 1 study in 27 results : IBA
  10. DNA (Deoxyribonucleic Acid) : 1 outcome 1 study in 20 results : IBA
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Diseases Related to Mixed Connective Tissue Disease

  1. Mixed Connective Tissue Disease (MCTD)
  2. Interstitial Lung Diseases (Interstitial Lung Disease)
  3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
  4. Systemic Scleroderma (Systemic Sclerosis)
  5. Glomerulonephritis
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Key Therapies for Mixed Connective Tissue Disease

Efficacy Chart >>
  1. Ketogenic Diet : 1 outcome 1 study in 2 results
  2. Drug Therapy (Chemotherapy) : 1 outcome in 3 results
  3. Thyroidectomy : 1 outcome in 2 results
  4. Aftercare (After-Treatment) : 1 study in 2 results
  5. Plasmapheresis : 7 results
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