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Marfan Syndrome (Marfan's Syndrome) Summary

Description: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.

Also Known As: Marfan's Syndrome; Marfans Syndrome; Syndrome, Marfan; Syndrome, Marfan's

Networked: 1272 relevant articles (20 outcomes, 88 trials/studies) for this Disease

Key Drugs and Agents for Marfan Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Losartan (Cozaar) : 4 outcomes 14 studies in 40 results : FDA 24 Generic
  2. fibrillin : 2 outcomes 27 studies in 434 results : IBA
  3. Atenolol (Tenormin) : 1 outcome 6 studies in 17 results : FDA 46 Generic
  4. Angiotensins : 1 outcome 5 studies in 5 results : IBA
  5. Transforming Growth Factor beta (TGF-beta) : 1 outcome 4 studies in 48 results : IBA
  6. DNA (Deoxyribonucleic Acid) : 1 outcome 2 studies in 18 results : IBA
  7. Angiotensin II : 1 outcome 2 studies in 12 results : IBA
  8. Doxycycline (Vibramycin) : 1 outcome 1 study in 5 results : FDA 23 Generic
  9. Angiotensin I : 1 outcome 1 study in 1 result : IBA
  10. Angiotensin Receptors (Angiotensin II Receptor) : 1 outcome in 8 results : IBA
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Diseases Related to Marfan Syndrome

  1. Aortic Aneurysm (Aneurysm, Aortic)
  2. Aneurysm (Aneurysms)
  3. Ectopia Lentis
  4. Thoracic Aortic Aneurysm
  5. Hypertension (High Blood Pressure)
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Key Therapies for Marfan Syndrome

Efficacy Chart >>
  1. Transplants (Transplant) : 1 outcome 4 studies in 112 results
  2. Prostheses and Implants (Prosthesis) : 1 outcome 1 study in 9 results
  3. Palatal Expansion Technique : 1 outcome 1 study in 2 results
  4. Mandibular Advancement : 1 outcome 1 study in 1 result
  5. Lenses : 1 outcome in 26 results
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