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Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme) Summary

Description: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.

Also Known As: Angiotensin Converting Enzyme; Angiotensin I-Converting Enzyme; Carboxycathepsin; Dipeptidyl Peptidase A; Kininase A Show All >>

Networked: 10643 relevant articles (587 outcomes, 1843 trials/studies) for this Bio-Agent

Key Diseases for which Peptidyl-Dipeptidase A is Relevant

  1. Hypertension (High Blood Pressure) : 140 outcomes 388 studies in 2277 results
  2. Heart Failure : 139 outcomes 281 studies in 1544 results
  3. Proteinuria : 36 outcomes 55 studies in 353 results
  4. Myocardial Infarction : 33 outcomes 177 studies in 713 results
  5. Diabetic Nephropathies (Diabetic Nephropathy) : 31 outcomes 75 studies in 342 results
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Drugs Related to Peptidyl-Dipeptidase A

  1. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
  2. Captopril (Capoten)
  3. Enalapril
  4. Angiotensin Receptor Antagonists
  5. Angiotensin II
  6. Angiotensin Receptors (Angiotensin II Receptor)
  7. Angiotensins
  8. Perindopril
  9. Calcium Channels (Calcium Channel)
  10. Calcium
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Therapies Related to Peptidyl-Dipeptidase A

  1. Transplants (Transplant)
  2. Renal Dialysis (Hemodialysis)
  3. Drug Therapy (Chemotherapy)
  4. Surgical Instruments (Clip)
  5. Aftercare (After-Treatment)
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