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Darier Disease (Darier's Disease) Summary

Description: An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.

Also Known As: Darier's Disease; Acantholytic Dyskeratotic Epidermal Nevi; Acantholytic Dyskeratotic Epidermal Nevus; Acrokeratosis Verruciformis; Hopf Disease Show All >>

Networked: 319 relevant articles (28 outcomes, 25 trials/studies) for this Disease

Key Drugs and Agents for Darier Disease

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Etretinate : 3 outcomes 4 studies in 27 results : FDA 1
  2. Tretinoin (Retinoic Acid) : 3 outcomes 1 study in 14 results : FDA 27 Generic
  3. Acitretin : 3 outcomes 1 study in 10 results : FDA 1
  4. Vitamin A (Retinol) : 2 outcomes in 13 results : FDA 33 Generic
  5. Isotretinoin (Accutane) : 1 outcome 1 study in 19 results : FDA 6 Generic
  6. Retinoids : 1 outcome in 11 results : IBA
  7. tazarotene (Tazorac) : 1 outcome in 6 results : FDA 2
  8. alitretinoin : 1 outcome in 5 results : FDA 1
  9. adapalene (Differin) : 1 outcome in 4 results : FDA 9 Generic
  10. Cyclosporine (Ciclosporin) : 1 outcome in 3 results : FDA 20 Generic
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Diseases Related to Darier Disease

  1. Darier Disease (Darier's Disease)
  2. Benign Familial Pemphigus (Hailey Hailey Disease)
  3. Psoriasis (Pustulosis Palmaris et Plantaris)
  4. Hidradenitis Suppurativa
  5. Lamellar Ichthyosis (Harlequin Ichthyosis)
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Key Therapies for Darier Disease

Efficacy Chart >>
  1. Photochemotherapy (Photodynamic Therapy) : 2 outcomes in 5 results
  2. Radiotherapy : 2 outcomes in 3 results
  3. Dermabrasion : 1 outcome in 4 results
  4. Solid-State Lasers : 1 outcome in 1 result
  5. Induced Hyperthermia (Thermotherapy) : 1 outcome in 1 result
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