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Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) Summary

Description: A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))

Also Known As: Creutzfeldt-Jakob Disease; Encephalopathy, Subacute Spongiform; Subacute Spongiform Encephalopathy; Syndrome, Creutzfeldt-Jakob; CJD (Creutzfeldt-Jakob Disease) Show All >>

Networked: 1557 relevant articles (8 outcomes, 88 trials/studies) for this Disease

Key Drugs and Agents for Creutzfeldt-Jakob Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. 14-3-3 Proteins (14-3-3 Protein) : 2 outcomes 6 studies in 75 results : IBA
  2. Acquired CJD : 1 outcome 7 studies in 40 results : IBA
  3. Prions : 1 outcome 4 studies in 200 results : IBA
  4. Amyloid (Amyloid Fibrils) : 1 outcome 3 studies in 97 results : IBA
  5. Growth Hormone (Somatotropin) : 1 outcome 3 studies in 70 results : IBA
  6. PrPSc Proteins : 1 outcome 3 studies in 41 results : IBA
  7. Paraffin : 1 outcome 2 studies in 12 results : IBA
  8. Formaldehyde (Formol) : 1 outcome in 15 results : FDA 1
  9. Recombinant DNA (Recombinant DNA Research) : 1 outcome in 1 result : IBA
  10. Codon (Codons) : 8 studies in 195 results : IBA
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Diseases Related to Creutzfeldt-Jakob Syndrome

  1. Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
  2. Scrapie
  3. Bovine Spongiform Encephalopathy (Mad Cow Disease)
  4. Kuru
  5. Alzheimer Disease (Alzheimer's Disease)
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Key Therapies for Creutzfeldt-Jakob Syndrome

Efficacy Chart >>
  1. Homologous Transplantation (Allograft) : 2 outcomes in 7 results
  2. Blood Transfusion (Blood Transfusions) : 5 studies in 79 results
  3. Transplants (Transplant) : 1 study in 86 results
  4. Nursing Care : 1 study in 4 results
  5. Lenses : 1 study in 1 result
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