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Histone Deacetylases (Histone Deacetylase) Summary

Description: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.

Also Known As: Histone Deacetylase; Class I Histone Deacetylases; Class II Histone Deacetylases; HDAC Proteins; Histone Deacetylase Complexes Show All >>

Networked: 2514 relevant articles (80 outcomes, 265 trials/studies) for this Bio-Agent

Key Diseases for which Histone Deacetylases is Relevant

  1. Neoplasms (Cancer) : 29 outcomes 93 studies in 1035 results
  2. Neurodegenerative Diseases (Neurodegenerative Disease) : 6 outcomes 3 studies in 46 results
  3. Breast Neoplasms (Breast Cancer) : 4 outcomes 18 studies in 86 results
  4. Huntington Disease (Huntington's Disease) : 3 outcomes 2 studies in 23 results
  5. Colonic Neoplasms (Colon Cancer) : 2 outcomes 6 studies in 31 results
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Drugs Related to Histone Deacetylases

  1. Histone Deacetylase Inhibitors
  2. DNA (Deoxyribonucleic Acid)
  3. vorinostat (suberoylanilide hydroxamic acid)
  4. Valproic Acid (Valproate, Semisodium)
  5. Enzymes
  6. trichostatin A (A 300)
  7. Proteasome Endopeptidase Complex (Proteasome)
  8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
  9. LBH589
  10. Histones (Histone)
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Therapies Related to Histone Deacetylases

  1. Drug Therapy (Chemotherapy)
  2. Therapeutics
  3. Ligation
  4. Heterologous Transplantation (Xenotransplantation)
  5. Aftercare (After-Treatment)
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