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Hirudins Summary

Description: Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.

Also Known As: Hirudin

Networked: 582 relevant articles (68 outcomes, 91 trials/studies) for this Bio-Agent

Key Diseases for which Hirudins is Relevant

  1. Thrombosis (Thrombus) : 22 outcomes 12 studies in 158 results
  2. Myocardial Infarction : 7 outcomes 21 studies in 44 results
  3. Acute Coronary Syndrome : 6 outcomes 17 studies in 31 results
  4. Hemorrhage : 6 outcomes 15 studies in 101 results
  5. Venous Thrombosis (Deep-Vein Thrombosis) : 6 outcomes 5 studies in 44 results
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Drugs Related to Hirudins

  1. Heparin (Liquaemin)
  2. Thrombin
  3. Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
  4. lepirudin (Refludan)
  5. desirudin (Iprivask)
  6. Enoxaparin (Lovenox)
  7. bivalirudin (Angiomax)
  8. Antithrombins
  9. argatroban (MPQA)
  10. ximelagatran (Exanta)
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Therapies Related to Hirudins

  1. Angioplasty (Angioplasty, Transluminal)
  2. Renal Dialysis (Hemodialysis)
  3. Cardiopulmonary Bypass (Heart-Lung Bypass)
  4. Thrombolytic Therapy
  5. Renal Replacement Therapy (Therapies, Renal Replacement)
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