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Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) Summary

Description: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.

Also Known As: Glomerulosclerosis, Focal; Glomerulosclerosis, Focal Segmental; Hyalinosis, Segmental; Segmental Glomerular Hyalinosis; Focal Glomerulosclerosis Show All >>

Networked: 1587 relevant articles (77 outcomes, 122 trials/studies) for this Disease

Key Drugs and Agents for Focal Segmental Glomerulosclerosis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Cyclosporine (Ciclosporin) : 14 outcomes 11 studies in 78 results : FDA 20 Generic
  2. Idiopathic minimal change nephrotic syndrome : 11 outcomes 37 studies in 388 results : IBA
  3. Prednisone (Sone) : 6 outcomes 1 study in 20 results : FDA 119 Generic
  4. Cyclophosphamide (Cytoxan) : 4 outcomes 2 studies in 36 results : FDA 10 Generic
  5. Tacrolimus (Prograf) : 4 outcomes 1 study in 18 results : FDA 7 Generic
  6. Methylprednisolone : 4 outcomes in 12 results : FDA 18 Generic
  7. Prednisolone (Predate) : 3 outcomes 1 study in 10 results : FDA 55 Generic
  8. Steroids : 2 outcomes 3 studies in 26 results : IBA
  9. rituximab (Mabthera) : 2 outcomes 2 studies in 47 results : FDA 3
  10. Creatinine : 2 outcomes 2 studies in 30 results : IBA
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Diseases Related to Focal Segmental Glomerulosclerosis

  1. Nephrotic Syndrome (Syndrome, Nephrotic)
  2. Proteinuria
  3. Membranous Glomerulonephritis (Membranous Nephropathy)
  4. Glomerulonephritis
  5. IGA Glomerulonephritis (IGA Nephropathy)
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Key Therapies for Focal Segmental Glomerulosclerosis

Efficacy Chart >>
  1. Plasmapheresis : 5 outcomes 1 study in 30 results
  2. Kidney Transplantation : 4 outcomes 5 studies in 133 results
  3. Transplantation (Transplant Recipients) : 4 outcomes 2 studies in 78 results
  4. Transplants (Transplant) : 3 outcomes 7 studies in 137 results
  5. Homologous Transplantation (Allograft) : 2 outcomes 6 studies in 73 results
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