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Ependymoma Summary

Description: Glioma derived from ependymocytes that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)

Also Known As: Anaplastic Ependymoma; Cellular Ependymoma; Clear Cell Ependymoma; Papillary Ependymoma; Anaplastic Ependymomas Show All >>

Networked: 894 relevant articles (23 outcomes, 106 trials/studies) for this Disease

Key Drugs and Agents for Ependymoma

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Etoposide (VP 16) : 2 outcomes 5 studies in 19 results : FDA 16 Generic
  2. bevacizumab : 2 outcomes 4 studies in 11 results : FDA 2
  3. Protons (Proton) : 2 outcomes 1 study in 18 results : IBA
  4. Cisplatin (Platino) : 2 outcomes in 7 results : FDA 6 Generic
  5. irinotecan (Camptosar) : 1 outcome 2 studies in 5 results : FDA 19 Generic
  6. temozolomide (Temodar) : 1 outcome 1 study in 11 results : FDA 3 Generic
  7. Estrogens (Estrogen) : 1 outcome 1 study in 6 results : FDA 1
  8. Cyclophosphamide (Cytoxan) : 1 outcome 1 study in 6 results : FDA 10 Generic
  9. Carboplatin (JM8) : 1 outcome 1 study in 5 results : FDA 29 Generic
  10. Aromatase (CYP19) : 1 outcome in 1 result : IBA
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Diseases Related to Ependymoma

  1. Neoplasms (Cancer)
  2. Medulloblastoma
  3. Astrocytoma (Pilocytic Astrocytoma)
  4. Brain Neoplasms (Brain Tumor)
  5. Glioblastoma (Glioblastoma Multiforme)
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Key Therapies for Ependymoma

Efficacy Chart >>
  1. Radiotherapy : 9 outcomes 14 studies in 160 results
  2. Drug Therapy (Chemotherapy) : 7 outcomes 20 studies in 98 results
  3. Aftercare (After-Treatment) : 1 outcome 1 study in 10 results
  4. Salvage Therapy : 1 outcome in 3 results
  5. Adjuvant Chemotherapy : 4 studies in 15 results
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