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Disulfiram (Antabuse) Summary

Description: A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

Also Known As: Antabuse; Antabus; Alcophobin; Allphar Brand of Disulfiram; Altana Pharma Brand of Disulfiram Show All >>

Networked: 969 relevant articles (64 outcomes, 102 trials/studies) for this Drug

Key Diseases for which Disulfiram is Relevant

  1. Alcoholism (Alcohol Abuse) : 24 outcomes 34 studies in 380 results
  2. Cocaine-Related Disorders (Cocaine Addiction) : 15 outcomes 18 studies in 49 results
  3. Neoplasms (Cancer) : 4 outcomes 11 studies in 72 results
  4. Poisoning : 3 outcomes 3 studies in 39 results
  5. Post-Traumatic Stress Disorders (PTSD) : 3 outcomes 2 studies in 5 results
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Drugs Related to Disulfiram

  1. Cocaine (Cocaine HCl)
  2. Methadone (Dolophine)
  3. Naltrexone (ReVia)
  4. Aldehyde Dehydrogenase
  5. Nickel
  6. Cyanamide (Calcium Carbimide)
  7. Carbon Monoxide
  8. Butylated Hydroxyanisole (BHA)
  9. Ditiocarb (Sodium Diethyldithiocarbamate)
  10. Dopamine (Intropin)
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Therapies Related to Disulfiram

  1. Drug Therapy (Chemotherapy)
  2. Oral Administration
  3. Chelation Therapy (Therapy, Chelation)
  4. Lenses
  5. Enterosorption
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