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Cytochrome P-450 Enzyme System (Cytochrome P450) Summary

Description: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

Also Known As: Cytochrome P450; Cytochrome P 450; Cytochrome P-450; Cytochrome P-450 Monooxygenase; Cytochrome P-450 Oxygenase Show All >>

Networked: 3623 relevant articles (84 outcomes, 414 trials/studies) for this Bio-Agent

Key Diseases for which Cytochrome P-450 Enzyme System is Relevant

  1. Neoplasms (Cancer) : 12 outcomes 50 studies in 559 results
  2. Body Weight (Weight, Body) : 6 outcomes 8 studies in 118 results
  3. Inflammation : 5 outcomes 7 studies in 144 results
  4. Hemorrhage : 4 outcomes 6 studies in 40 results
  5. Fibrosis (Cirrhosis) : 4 outcomes 5 studies in 43 results
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Drugs Related to Cytochrome P-450 Enzyme System

  1. Enzymes
  2. Isoenzymes
  3. Cytochrome P-450 CYP1A2 (CYP1A2)
  4. Omeprazole (Esomeprazole)
  5. Aromatase (CYP19)
  6. Antipyrine (Phenazone)
  7. Cytochromes b5 (Cytochrome b5)
  8. Glutathione Transferase (Glutathione S-Transferase)
  9. Protein Isoforms (Isoforms)
  10. Acids
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Therapies Related to Cytochrome P-450 Enzyme System

  1. Drug Therapy (Chemotherapy)
  2. Castration
  3. Total Parenteral Nutrition
  4. Transplants (Transplant)
  5. Resuscitation
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