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Charcot-Marie-Tooth Disease
(Peroneal Muscular Atrophy)
Summary
Description:
A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
Also Known As:
Peroneal Muscular Atrophy; Roussy Levy Syndrome; Syndrome, Roussy-Levy; Charcot-Marie Disease; Charcot-Marie-Tooth Disease, Type I Show All >>
Networked: 546
relevant articles (7 outcomes,
38 trials/studies)
for this Disease
Key Drugs and Agents for Charcot-Marie-Tooth Disease
Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
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tebufenozide (Mimic)
:
1 outcome in 4 results
: IBA
-
Tea
:
1 outcome in 1 result
: IBA
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Prednisolone (Predate)
:
1 outcome in 1 result
:
FDA 55
Generic
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Curcumin
:
1 outcome in 1 result
: IBA
-
pioglitazone (Actos)
:
1 outcome in 1 result
:
FDA 9
-
resveratrol
:
1 outcome in 1 result
: IBA
-
gallocatechol (epigallocatechin)
:
1 outcome in 1 result
: IBA
-
modafinil (armodafinil)
:
1 outcome in 1 result
:
FDA 10
-
connexin 32
:
3 studies in 56 results
: IBA
-
Dynamin II
:
2 studies in 8 results
: IBA
Show All >>
Diseases Related to Charcot-Marie-Tooth Disease
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Myotonic Dystrophy (Dystrophia Myotonica)
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Spinal Muscular Atrophy (Progressive Muscular Atrophy)
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Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
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Friedreich Ataxia (Friedreich's Ataxia)
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Neuromuscular Diseases (Neuromuscular Disease)
Show All >>
Key Therapies for Charcot-Marie-Tooth Disease
Efficacy Chart >>
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Resistance Training
:
2 outcomes 2 studies in 7 results
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Orthotic Devices (Orthosis)
:
3 studies in 6 results
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Osteotomy
:
1 study in 8 results
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Arthrodesis
:
1 study in 6 results
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Denervation
:
1 study in 5 results
Show All >>
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