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Camptothecin Summary

Description: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Also Known As: Camptothecine; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-

Networked: 1416 relevant articles (77 outcomes, 234 trials/studies) for this Bio-Agent

Key Diseases for which Camptothecin is Relevant

  1. Neoplasms (Cancer) : 42 outcomes 84 studies in 639 results
  2. Carcinoma (Carcinomatosis) : 5 outcomes 14 studies in 97 results
  3. Breast Neoplasms (Breast Cancer) : 3 outcomes 14 studies in 73 results
  4. Colonic Neoplasms (Colon Cancer) : 3 outcomes 7 studies in 48 results
  5. Melanoma (Melanoma, Malignant) : 3 outcomes 5 studies in 42 results
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Drugs Related to Camptothecin

  1. Type I DNA Topoisomerases (Topoisomerase I)
  2. irinotecan (Camptosar)
  3. Cisplatin (Platino)
  4. Polymers
  5. Topotecan (Hycamtin)
  6. Doxorubicin (Adriamycin)
  7. DNA (Deoxyribonucleic Acid)
  8. Topoisomerase I Inhibitors
  9. Paclitaxel (Taxol)
  10. belotecan
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Therapies Related to Camptothecin

  1. Heterologous Transplantation (Xenotransplantation)
  2. Drug Therapy (Chemotherapy)
  3. Microspheres (Microsphere)
  4. Aftercare (After-Treatment)
  5. Therapeutics
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