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Calpain Summary

Description: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.

Also Known As: Ca2+-Activated Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calpain I Show All >>

Networked: 1539 relevant articles (40 outcomes, 209 trials/studies) for this Bio-Agent

Key Diseases for which Calpain is Relevant

  1. Ischemia : 6 outcomes 20 studies in 145 results
  2. Brain Injuries (Brain Injury) : 3 outcomes 9 studies in 78 results
  3. Anoxia (Hypoxia) : 3 outcomes 8 studies in 70 results
  4. Neoplasms (Cancer) : 2 outcomes 8 studies in 91 results
  5. Necrosis : 2 outcomes 7 studies in 76 results
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Drugs Related to Calpain

  1. calpain inhibitors
  2. Caspase 3 (Caspase-3)
  3. calpeptin
  4. Calcium
  5. Proteins (Proteins, Gene)
  6. calpain inhibitor III
  7. Spectrin
  8. Cysteine Proteases (Cysteine Protease)
  9. Proteasome Endopeptidase Complex (Proteasome)
  10. Ubiquitin
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Therapies Related to Calpain

  1. Lenses
  2. Drug Therapy (Chemotherapy)
  3. Ischemic Postconditioning
  4. Protein-Restricted Diet (Diet, Protein Restricted)
  5. Mechanical Ventilators (Ventilator)
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