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Busulfan (Busulfex) Summary

Description: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.

Also Known As: Busulfex; Myleran; Busulfan Wellcome; Glaxo Wellcome Brand of Busulfan; GlaxoSmithKline Brand of Busulfan; Glyzophrol; Myelosan; Mylecytan; Myléran; Orphan Brand of Busulfan; Wellcome Brand of Busulfan; n-Butane-1,3-di(methylsulfonate); Busulfan GlaxoSmithKline Brand; Busulfan Orphan Brand; Busulfan Wellcome Brand; Wellcome, Busulfan; Busulphan; 1,4-Butanediol, dimethanesulfonate

Networked: 1454 relevant articles (121 outcomes, 164 trials/studies) for this Drug

Key Diseases for which Busulfan is Relevant

  1. Acute Myeloid Leukemia (Acute Myelogenous Leukemia) : 34 outcomes 12 studies in 115 results
  2. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) : 20 outcomes 19 studies in 233 results
  3. Leukemia : 14 outcomes 17 studies in 142 results
  4. Myelodysplastic Syndromes (Myelodysplastic Syndrome) : 7 outcomes 4 studies in 54 results
  5. Hematologic Neoplasms (Hematological Malignancy) : 5 outcomes 15 studies in 78 results
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Drugs Related to Busulfan

  1. Cyclophosphamide (Cytoxan)
  2. fludarabine
  3. Melphalan (Alkeran)
  4. Thiotepa (Triethylenethiophosphoramide)
  5. Etoposide (VP 16)
  6. Hydroxyurea (Hydrea)
  7. Antilymphocyte Serum (Anti-Thymocyte Globulin)
  8. Interferon-alpha (Interferon Alfa)
  9. thymoglobulin
  10. Interferons
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Therapies Related to Busulfan

  1. Hematopoietic Stem Cell Transplantation
  2. Transplantation (Transplant Recipients)
  3. Drug Therapy (Chemotherapy)
  4. Stem Cell Transplantation
  5. Bone Marrow Transplantation (Transplantation, Bone Marrow)
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