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Brain Death (Brain Dead) Summary

Description: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)

Also Known As: Brain Dead; Irreversible Coma; Brain Deads; Coma, Irreversible; Death, Brain Show All >>

Networked: 2313 relevant articles (76 outcomes, 226 trials/studies) for this Disease

Key Drugs and Agents for Brain Death

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Norepinephrine (Noradrenaline) : 3 outcomes 4 studies in 30 results : FDA 5 Generic
  2. Acetylcysteine (Siran) : 3 outcomes 1 study in 3 results : FDA 17 Generic
  3. Dopamine (Intropin) : 2 outcomes 5 studies in 31 results : FDA 36 Generic
  4. Epinephrine (Adrenaline) : 2 outcomes 5 studies in 29 results : FDA 93 Generic
  5. Triiodothyronine (Liothyronine) : 2 outcomes 4 studies in 31 results : FDA 1 Generic
  6. barbituric acid (barbiturate) : 2 outcomes 4 studies in 23 results : IBA
  7. Cytokines : 2 outcomes 2 studies in 30 results : IBA
  8. Messenger RNA (mRNA) : 2 outcomes 2 studies in 18 results : IBA
  9. Technetium Tc 99m Exametazime (Ceretec) : 2 outcomes 2 studies in 16 results : FDA 1
  10. urinastatin (MR 20) : 2 outcomes 1 study in 4 results : IBA
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Diseases Related to Brain Death

  1. Apnea
  2. Death (Near-Death Experience)
  3. Ischemia
  4. Inflammation
  5. Shock
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Key Therapies for Brain Death

Efficacy Chart >>
  1. Transplants (Transplant) : 15 outcomes 34 studies in 525 results
  2. Transplantation (Transplant Recipients) : 9 outcomes 22 studies in 427 results
  3. Homologous Transplantation (Allograft) : 2 outcomes 9 studies in 100 results
  4. Resuscitation : 2 outcomes 9 studies in 76 results
  5. Liver Transplantation : 2 outcomes 7 studies in 88 results
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